Molecular Mimicry Mapping in Streptococcus pneumoniae: Cues for Autoimmune Disorders and Implications for Immune Defense Activation

Streptococcus pneumoniae contributes to a range of infections, including meningitis, pneumonia, otitis media, and sepsis. Infections by this bacterium have been associated with the phenomenon molecular mimicry, which, in turn, may contribute induction autoimmunity. In study, we utilized bioinformatics approach investigate potential for S. incite autoimmunity via mimicry. We identified 13 proteins that significant sequence similarity human proteins, 11 them linked autoimmune disorders such as psoriasis, rheumatoid arthritis, diabetes. Using silico tools, predicted well structural homology among these proteins. Database mining was conducted establish links between disorders. The antigenic, non-allergenic, immunogenic mimics were employed design validate an immune response vaccine construct design. Mimic-based can prove effective immunization against infections. Immune simulation binding affinity assessed through docking C8 leukocyte antigen (HLA) molecules TLR4 receptor, promising results. Additionally, mapped conserved regions on their respective suggesting functional importance pathogenesis. This study highlights trigger mimicry possibility using triggering defense response.